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Novel Coronavirus Disease (COVID-19): An extensive study on evolution, global health, drug targets and vaccines

Khan Abdul Ashik, Dutta Tanmoy, Mondal Palas, Mandal Manab, Chowdhury Swapan Kumar, Ahmed Minhajuddin, Baildya Nabajyoti, Mazumdar Sourav,

Abstract: The Coronavirus disease-2019 (COVID-19), has become a worldwide pandemic and the scientific communities are struggling to find out the ultimate treatment strategies against this lethal virus, Severe Acute Respiratory Syndrome Coronavirus–2 (SARS-CoV-2). Presently, there is no potential chemically proven antiviral therapy available in the market which can effectively combat the infection caused by this deadly virus. Few vaccines are already developed but it is not clear to the scientific community how much efficient they are to combat SARS-CoV-2. Mode of transmission and symptoms of the disease are two important factors in this regard. Rapid diagnosis of the COVID-19 is very much important to stop its spreading. In this scenario, a complete study starting from symptoms of the disease to vaccine development including various SARS-CoV-2 detection techniques is very much required. In this review article, we have made a partial analysis on the origin, virology, global health, detection techniques, replication pathways, doses, mode of actions of probable drugs, and vaccine development for SARS-CoV-2.
Keywords: vaccine / mode of actions / evolution / antiviral / Coronavirus / COVID / combat / drugs / treatment

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