Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population
Open Access
- 29 November 2017
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 37 (6)
- https://doi.org/10.1042/bsr20171088
Abstract
Ischemic stroke (IS), the leading neurology cause of death and disability worldwide, is influenced by gene polymorphisms. To explore the association between IS and Apolipoprotein E ( APOE ) gene polymorphisms, a case-control study containing 513 IS patients and 514 controls without IS was conducted in a Northwest China Han population. MassARRAY iPLEX system was applied to determine the APOE polymorphisms according to the alleles of two single nucleotide polymorphisms (SNPs) of APOE, rs429358 and rs7412. The results showed that rs429358 and rs7412 were in Hardy-Weinberg equilibrium (HWE) in both cases and control groups. APOE ε4 allele, ε4/ε4 genotype and ε4-containing genotypes were associated with IS. According to the results of Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification system, APOE ε2 allele, ε4 allele and ε4/ε4 genotype were associated with large artery atherosclerosis IS subtypes. In addition, the results also indicated that the ε4 allele related to undetermined IS and ε4/ε4 genotype was related to small vessel disease IS. Compared to subjects with non-ε4-containing genotypes, the total cholesterol (TC) and low-density lipoprotein (LDL) level in blood and the proportion of cardiopath history were higher in all subjects with ε4-containing genotypes. Besides, the triacylglycerides (TG) level in blood was higher in controls with ε4-containing genotypes. In conclusion, in a Northwest China Han population, APOE ε4 allele was associated with blood lipid level. The TC and LDL levels were the independent risk factors for IS. APOE was a risk gene for IS, but not independent, especially for large artery atherosclerosis IS.Keywords
This publication has 33 references indexed in Scilit:
- HDAC9 gene is associated with stroke risk in a Chinese populationExperimental Biology and Medicine, 2013
- Association between Apolipoprotein E Gene Polymorphism and the Risk of Coronary Artery Disease in Chinese Population: Evidence from a Meta-Analysis of 40 StudiesPLOS ONE, 2013
- Association between the apolipoprotein E gene polymorphism and ischemic stroke in Chinese populations: New data and meta-analysisExperimental and Therapeutic Medicine, 2012
- The China National Stroke Registry for Patients with Acute Cerebrovascular Events: Design, Rationale, and Baseline Patient CharacteristicsInternational Journal of Stroke, 2011
- APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA StudyAge and Ageing, 2009
- Genomewide Association Studies of StrokeThe New England Journal of Medicine, 2009
- Association between apolipoprotein E genotype and carotid intima-media thickness may suggest a specific effect on large artery atherothrombotic stroke.Stroke, 2007
- Association of Apolipoprotein E Polymorphism with Ischemic Stroke Subtypes in TaiwanThe Kaohsiung Journal of Medical Sciences, 2007
- Association between apolipoprotein E polymorphism and serum lipid and apolipoprotein levels with Alzheimer's diseaseNeuroscience Letters, 2006
- Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset FamiliesScience, 1993