Full range characterization of the Raman spectra of organs in a murine model
- 27 October 2011
- journal article
- Published by Optica Publishing Group in Optics Express
- Vol. 19 (23), 22892-22909
- https://doi.org/10.1364/oe.19.022892
Abstract
Raman spectroscopy is a minimally-invasive optical technique with great potential for in vivo cancer detection and disease diagnosis. However, there is no systematic study of the Raman spectra from different organs to date. We measured and characterized the Raman spectra eighteen naïve mouse organs in a broad frequency range of 700 to 3100 cm−1. The peaks of generic proteins and lipids appeared in Raman spectra of all organs. Some organs like bone, teeth, brain and lung had unique Raman peaks. The autofluorescence was strong in liver, spleen, heart, and kidney. These results suggest that organ specific Raman probe design and specific data processing strategies are required in order to get the most useful information.This publication has 49 references indexed in Scilit:
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