Thiol Disulfide Homeostasis of Pediatric Oncology Patients After the Positron Emission Tomography/Computerized Tomography Imaging: A Cross-Sectional Study
- 1 September 2021
- journal article
- research article
- Published by Galenos Yayinevi in Medical Bulletin of Haseki
- Vol. 59 (4), 324-329
- https://doi.org/10.4274/haseki.galenos.2021.7307
Abstract
Aim: Positron emission tomography/computerized tomography (PET/CT) is used for oncologic imaging as hybrid imaging. Pediatric patients are exposed to ionizing radiation when they undergo hybrid medical imaging examinations. It is especially important to minimize the radiation exposure when children and infants are imagined, as immature tissues are more susceptible to damage induced by radiation. This study aims to reveal the oxidant and antioxidant status in oncology patients before and after PET/CT imaging. Methods: Between February 2019 and July 2019, pediatric oncology patients who underwent PET imaging at the time of diagnosis in our center were included in the study. Eighteen newly diagnosed cancer pediatric patients participated in this prospective crosssectional study. Data were saved to synchronously kept excel log files and used in the study. Disulphide amounts, total and native thiols, native thiol/total thiol percent ratios, disulphide/native thiol percent ratios, disulphide/total thiol percent ratios, and Ischemia-Modified Albumin were calculated before and after the PET/CT imaging. Results: Disulphide levels, disulphide/total thiol and disulphide/native thiol ratios of patients' serum samples were significantly higher and the ratio of native thiol/total thiol was reduced after the PET/CT. Conclusion: There was disturbed thiol-disulfide homeostasis and the balance changed in the direction of oxidant damage. Our results indicate the possible oxidative stress condition due to radiation exposure with PET/CT in pediatric oncology patients.Keywords
This publication has 16 references indexed in Scilit:
- Assessment of Sequential PET/MRI in Comparison With PET/CT of Pediatric Lymphoma: A Prospective StudyAmerican Journal of Roentgenology, 2016
- A novel and automated assay for thiol/disulphide homeostasisClinical Biochemistry, 2014
- Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano ClassificationJournal of Clinical Oncology, 2014
- Role of Imaging in the Staging and Response Assessment of Lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working GroupJournal of Clinical Oncology, 2014
- Implications for human and environmental health of low doses of ionising radiationJournal of Environmental Radioactivity, 2014
- Nuclear Medicine in the First Year of LifeJournal of Nuclear Medicine, 2011
- Estimated cumulative radiation dose from PET/CT in children with malignancies: a 5-year retrospective reviewPediatric Radiology, 2009
- Diagnostic value of PET/CT for the staging and restaging of pediatric tumorsEuropean Journal of Nuclear Medicine and Molecular Imaging, 2008
- 18F-FDG PET/CT in Evaluating Non-CNS Pediatric MalignanciesJournal of Nuclear Medicine, 2007
- Molecular imaging of cancer with positron emission tomographyNature Reviews Cancer, 2002