SARS-COV-2 Induce Pulmonary Injury from Basic to Clinical Research
Open Access
- 1 January 2022
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in World Journal of Cardiovascular Diseases
- Vol. 12 (03), 168-190
- https://doi.org/10.4236/wjcd.2022.123018
Abstract
The SARS-CoV-2 has infected over 194,909,000 cases and over 4,170,000 deaths in the world before the end of July 2021. The virus attacks human alveoli and induces severe lung injury (COVID-19 disease) and spreads rapidly. The mechanisms of COVID-19 disease are unclear. To better understand this disease, This review analyzes the SARS-CoV-2 biological characteristics, insights the effect of alveolar epithelium and its adjacent microvascular endothelium, investigates human host cells immune response and immunothrombosis. Explains clinical manifestations of COVID-19 associated lung injury. It may be helpful for development management strategies for COVID-19 associated pulmonary damage.Keywords
This publication has 98 references indexed in Scilit:
- Coronavirus infections and immune responsesJournal of Medical Virology, 2020
- Acute respiratory distress syndromeNature Reviews Disease Primers, 2019
- A Role for Neutrophils in Viral Respiratory DiseaseFrontiers in Immunology, 2017
- Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathologySeminars in Immunopathology, 2017
- Angiotensin II-Induced Early and Late Inflammatory Responses Through NOXs and MAPK PathwaysInflammation, 2016
- Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli SepsisBlood, 2015
- Into the Eye of the Cytokine StormMicrobiology and Molecular Biology Reviews, 2012
- Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in miceJournal of Hepatology, 2010
- Human NK Cell Education by Inhibitory Receptors for MHC Class IImmunity, 2006
- Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesisThe Journal of Pathology, 2004