Evaluation of Relationship Between Tp-E Interval Values and QT Dispersion in Electrocardiogram in Children With B12 Vitamin Deficiency

Abstract

Aim: B12 vitamin deficiency may cause cardiac autonomic dysfunction, heart rate variability, endothelial dysfunction and subclinical atherosclerosis, a significant degree of reduction in heart ejection fraction and deformation of the left ventricular myocardium. We aimed to investigate the effect of B12 deficiency in children on cardiac electrical activity by comparing the Tp-e and QT dispersion values between healthy children and children with B12 deficiency. Methods: The demographic data, laboratory results electrocardiography and echocardiography results of isolated B12 patients (n=64) with vitamin B12 deficiency and control group (n=64) included in the study between 15.3.2020 and 15.06.2020 were prospectively recorded and comparatively analyzed. Results: A total of 128 patients included in the study. Corrected QT (QTc) value and Tp-e interval, were statistically significantly higher in the patient group (p<0.05). Tp-e/QT and Tp-e/QTc ratios in the patient groups were statistically significantly higher than the ones in the control group (p<0.05). Conclusion: Repolarization differences in B12 deficient children when compared to those of healthy children, might reflect subclinical symptoms.