A direct method for the N-tetraalkylation of azamacrocycles
Open Access
- 18 November 2016
- journal article
- Published by Beilstein Institut in Beilstein Journal of Organic Chemistry
- Vol. 12 (1), 2457-2461
- https://doi.org/10.3762/bjoc.12.239
Abstract
An efficient protocol for the direct synthesis of N-tetraalkylated derivatives of the azamacrocycles cyclam and cyclen has been developed, using a partially miscible aqueous–organic solvent system with propargyl bromide, benzyl bromide, and related halides. The method works most effectively when the reaction mixture is shaken, not stirred. A crystal structure of the N-tetrapropargyl cyclam derivative 1,4,8,11-tetra(prop-2-yn-1-yl)-1,4,8,11-tetraazacyclotetradecane diperchlorate is reported.Keywords
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