Intestinal microbiota and related metabolites are essential mediators for adoptive γδT cell antitumor immunotherapy

Abstract

Intestinal microbiotas modulate multiple biochemical reactions and immune hemostasis of the host, numerous pieces of evidence have revealed that they are also tightly involved in the efficacy of antitumor immunotherapy. However,s which way local intestinal microbiota influences the activity of distant organs is still unknown. In this review, we highlighted the importance of metabolites produced by intestinal microbiotas which disorder prompted cytotoxic capability of adoptive γδT cells. The microbiota-metabolites-γδT cell axis is dominant in the antitumor immune response of adoptive γδT cell immunotherapy.