Perry and postoperative pain management remain an acute problem to this day. The intensity of pain depends on various objective and subjective factors, on the individual characteristics of the patient. The course and severity of acute postoperative pain determine the likelihood of developing chronic postoperative pain.Then. Multimodal analgesia is the effect on the peripheral and / or central nervous system, acting on drugs and techniques with different mechanisms of action (including non-pharmacological techniques), with synergistic and additive effects that can achieve higher quality analgesia than using these methods alone. Use low-dose medications to avoid dose-dependent side effects. Fractionation of analgesics at all stages of the perioperative period.Postoperative pain prevention should begin as soon as surgical treatment is planned. The multidisciplinary team of physicians, based on the conclusion made after assessing the patient's condition and risk factors, develops a perioperative plan for pain relief. Multimodal analgesia is unequivocally a priority and most effective in the world literature today.