Preparation and Properties of pH-Responsive Intelligent Medical Dressing Based on Bacterial Cellulose/Polyacrylic Acid
Open Access
- 1 January 2022
- journal article
- research article
- Published by Scientific Research Publishing, Inc. in Materials Sciences and Applications
- Vol. 13 (03), 107-131
- https://doi.org/10.4236/msa.2022.133008
Abstract
Bacterial cellulose/polyacrylic acid (BC/PAA) pH-responsive hydrogels were prepared by free-radical polymerization (in situ) using BC as the raw material and AA as the monomer. The hydrogels were loaded with curcumin (Cur) to prepare pH-responsive intelligent medical dressings. The preparation process of the hydrogels was optimized by a single factor and response surface experiment using their swelling degree as an index. The structures of BC/PAA pH-responsive hydrogels were characterized by scanning electron microscope (SEM), Fourier Transform Infrared spectrometer (FTIR), X-ray diffraction (XRD), and tensile tester, and the swelling properties, mechanical properties, bacteriostatic properties, and drug release behavior were investigated. The results showed that the BC/PAA pH-responsive hydrogel has a three-dimensional network structure with the swelling rate up to 1600 g/g, compressive strength of up to 8 KPa, and good mechanical properties, and the drug release behavior was in line with the logistic dynamics model, and it has good inhibitory effects on common pathogens of wound infection: E. coli, S. aureus, and P. aeruginosa.Keywords
This publication has 33 references indexed in Scilit:
- Biocompatible and Mucoadhesive Bacterial Cellulose-g-Poly(acrylic acid) Hydrogels for Oral Protein DeliveryMolecular Pharmaceutics, 2014
- Synthesis and Swelling Behavior of Novel pH Responsive Hydrogels for Environmental ApplicationsPolymer-Plastics Technology and Engineering, 2014
- Novel Chitosan-Functionalized Spherical Nanosilica Matrix As an Oral Sustained Drug Delivery System for Poorly Water-Soluble Drug CarvedilolACS Applied Materials & Interfaces, 2012
- Synthesis and characterization of thermo- and pH-responsive bacterial cellulose/acrylic acid hydrogels for drug deliveryCarbohydrate Polymers, 2012
- Superabsorbent hydrogel composite made of cellulose nanofibrils and chitosan-graft-poly(acrylic acid)Carbohydrate Polymers, 2012
- Statistical assessment of dissolution and drug release profile similarity using a model-dependent approachJournal of Pharmaceutical and Biomedical Analysis, 2007
- Thermosensitive poly(n‐isopropylacrylamide) hydrogels bonded on cellulose supportsJournal of Applied Polymer Science, 2003
- On the use of the Weibull model to describe thermal inactivation of microbial vegetative cellsInternational Journal of Food Microbiology, 2002
- Mechanisms of solute release from porous hydrophilic polymersInternational Journal of Pharmaceutics, 1983
- Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matricesJournal of Pharmaceutical Sciences, 1963