Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)
Open Access
- 26 April 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in Military Medical Research
- Vol. 9 (1), 1-15
- https://doi.org/10.1186/s40779-022-00380-5
Abstract
Granulomatous lobular mastitis (GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence. Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions, etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology. The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidence-based consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM.Keywords
Funding Information
- Improving the Ability of Diagnosis and Treatment of Difficult Diseases (ZLYNXM202009)
This publication has 86 references indexed in Scilit:
- Idiopathic Granulomatous Mastitis: An Autoimmune Disease?The Scientific World Journal, 2013
- Experience of treatment of patients with granulomatous lobular mastitisJournal of the Korean Surgical Society, 2013
- Idiopathic granulomatous mastitis associated with risperidone-induced hyperprolactinemiaDiagnostic Pathology, 2012
- Granulomatous Mastitis during Chronic Antidepressant Therapy: Is It Possible a Conservative Therapeutic Approach?Journal of Breast Cancer, 2012
- First Report of Idiopathic Granulomatous Mastitis Treated with Methotrexate MonotherapyThe Journal of Rheumatology, 2009
- Magnetic resonance imaging of breast lesions—a pathologic correlationBreast Cancer Research and Treatment, 2006
- Radiologic and Clinical Features of Idiopathic Granulomatous Lobular Mastitis Mimicking Advanced Breast CancerYonsei Medical Journal, 2006
- The Role of Conservative Treatment in Idiopathic Granulomatous MastitisThe Breast Journal, 2005
- Rheumatologists and breasts: immunosuppressive therapy for granulomatous mastitisRheumatology, 2004
- A clinicopathological review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitisPathology, 2003