Miller Fisher syndrome following COVID ‐19 vaccines: A scoping review
- 8 August 2022
- journal article
- review article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 146 (5), 604-609
- https://doi.org/10.1111/ane.13687
Abstract
Background and Purpose Miller Fisher syndrome (MFS), a variant of Guillain-Barre Syndrome (GBS), could be underestimated in evaluations of its adverse events (AEs) following COVID-19 vaccination. We aimed to identify and characterize MFS following COVID-19 vaccination. Materials and Methods Relevant studies reported on during the COVID-19 pandemic were identified in the MEDLINE, Embase, and other databases. Results Nine cases of MFS following COVID-19 vaccination from various regions were included. Unlike MFS following COVID-19 infection, patients with MFS following COVID-19 vaccination frequently presented with anti-GQ1b antibody positivity (44%, 4/9). Unlike GBS following COVID-19 vaccination, only two of nine (22%) cases of MFS following COVID-19 vaccination had developed after viral-vector-related vaccine administration. Conclusions Miller Fisher syndrome following COVID-19 vaccination seems to have a different pathophysiology from MFS following COVID-19 infection and GBS following COVID-19 vaccination. This neurological syndrome with a rare incidence and difficulty in diagnosis should be considered an AE of COVID-19 vaccination.Keywords
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