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Investigation of the Synthesis and Biological Activity of A New Imine Compound Containing Ferrocene and Benzothiazol

Neslihan Demir & Mustafa Yıldız Büşra Dalgıç, Çanakkale Onsekiz Mart University, Neslihan Demir, Mustafa Yıldız
International Journal of Innovative Approaches in Science Research , Volume 4, pp 52-65; doi:10.29329/ijiasr.2020.273.1

Abstract: In this study, a new Schiff base containing ferrocene and benzothiazol was synthesized from the reaction of ferrocene-2-carboxialdehyde and 6-methoxybenzo[d]thiazole-2-amine. The structure of the synthesized original imine compound 2-((6-methoxybenzo[d]thiazol-2-ylimino)methyl) ferrocene was illuminated by UV-VIS, FTIR, MS and NMR spectroscopy. The antimicrobial activity of the compound was determined by the minimum inhibition concentration (MIC) method against various bacterial and yeast cultures, and the antioxidant activity was determined by the free radical scavenging activity of 2,2-diphenyl-1-picrilhydrazyl (DPPH). DNA cleavage activity of Schiff base was investigated hydrolytically and oxidatively by agarose gel electrophoresis method, and binding to DNA was investigated by UV-Visible field spectroscopy method. It was found that the studied ferrocene and benzothiazole imine compound had more effect on Pseudomonas aeruginosa (ATCC 27853) and Bacillus subtilis (ATCC 6633) bacteria. The compound was found to exhibit good antioxidant activity compared to the standardized butylated hydroxy toluene (BHT). Agarose gel electrophoresis studies showed that the compound cleaved DNA without any external agent, and UV-Vis spectroscopy studies showed that it interacted electrostatically with CT-DNA.
Keywords: antioxidant / Electrophoresis / structure / ferrocene / thiazole / ATCC / imine compound / Methoxybenzo

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