Efficacy of Fractional Carbon Dioxide (CO2) Laser versus Q-Switched Neodymium-Doped Yttrium Aluminum Garnet (Nd:YAG) and Potassium-Titanyl-Phosphate (KTP) Lasers in the Treatment of Acanthosis Nigricans
Open Access
- 1 March 2023
- journal article
- research article
- Published by Taylor & Francis Ltd in Clinical, Cosmetic and Investigational Dermatology
- Vol. ume 16, 705-715
- https://doi.org/10.2147/ccid.s401479
Abstract
Background: Acanthosis nigricans (AN) is a common chronic skin disorder clinically presents by velvety hyperpigmented lesions mainly at the flexural areas. Fractional photothermolysis has been reported to improve both pigmentary and textural changes by removing thin layers of skin with minimal thermal damage. Other options are the Q-switched (Qs) Nd:YAG (1064 nm) and Qs KTP (532 nm) lasers. Both can induce collagen remodeling by dermal photo-mechanical microdamage. Aim of the Work: The aim of this study was to assess the clinical efficacy and the safety of fractional CO2 laser versus Qs Nd:YAG and KTP lasers in the treatment of acanthosis nigricans. Methods: This randomized-controlled split neck study was conducted on 23 patients suffering from AN. For each patient, one side of the neck was randomly assigned to fractional CO2 laser and the other side to Qs Nd:YAG and KTP lasers every four weeks for four months followed by 4 monthly follow-up assessment. Acanthosis Nigricans Area and Severity Index (ANASI) score, melanin and erythema indices as well as Patient Satisfaction Scale (PSS) were used to assess improvement on each side separately. Results: There was no statistically significant difference regarding the clinical improvement between the side treated with Fractional CO2 laser and the side treated with Qs Nd:YAG and KTP lasers (P value > 0.05). In most patients, both sides showed improvement during different sessions of therapy, as regards ANASI scores, melanin indices, patient satisfaction scores, and side effects. Conclusion: In this study, we concluded that both fractional CO2 and Q-switched lasers proved to be a safe and effective line of treatment of acanthosis nigricans.Keywords
This publication has 27 references indexed in Scilit:
- An approach to acanthosis nigricansIndian Dermatology Online Journal, 2014
- Fractional, nonablative Q-switched 1,064-nm neodymium YAG laser to rejuvenate photoaged skin: a pilot case series.2012
- A Split-Face Comparison of Two Ablative Fractional Carbon Dioxide Lasers for the Treatment of Photodamaged Facial SkinDermatologic Surgery, 2011
- A Split-Face Comparison of Two Ablative Fractional Carbon Dioxide Lasers for the Treatment of Photodamaged Facial SkinDermatologic Surgery, 2011
- Safe and Effective One-Session Fractional Skin Resurfacing Using a Carbon Dioxide Laser Device in Super-Pulse Mode: A Clinical and Histologic StudyAesthetic Plastic Surgery, 2010
- Fractional Photothermolysis for the Treatment of Postinflammatory HyperpigmentationDermatologic Surgery, 2009
- Fractional photothermolysis—an updateLasers in Medical Science, 2009
- Biostatistics 104: correlational analysis.2003
- Biostatistics 103: qualitative data - tests of independence.2003
- Combination 532-nm and 1064-nm Lasers for Noninvasive Skin Rejuvenation and ToningArchives of Dermatology, 2003