Liquid Copolymers as Biodegradable Surgical Sealant
- 3 June 2021
- journal article
- research article
- Published by Wiley in Advanced Healthcare Materials
- Vol. 10 (19), 2100803
- https://doi.org/10.1002/adhm.202100803
Abstract
Surgical sealants are widely used to prevent seepage of fluids and liquids, promote hemostasis, and close incisions. Despite the remarkable progress the field of biomaterials has undergone, the clinical uses of surgical sealants are limited because of their short persistence time in vivo, toxicity, and high production costs. Here, the development of two complementary neat (solvent-free) prepolymers, PEG4-PLGA-NHS and PEG4-NH2, that harden upon mixing to yield an elastic biodegradable sealant is presented. The mechanical and rheological properties and cross-linking rate can be controlled by varying the ratio between the two prepolymers. The tested sealants show a longer persistence time compared with fibrin glue, minimal cytotoxicity in vitro, and excellent biocompatibility in vivo. The neat, multiarmed approach demonstrated here improves the mechanical and biocompatibility properties and provides a promising tissue sealant solution for wound closure in future surgical procedures.This publication has 45 references indexed in Scilit:
- Instant tough bioadhesive with triggerable benign detachmentProceedings of the National Academy of Sciences of the United States of America, 2020
- The potential effect of biological sealants on colorectal anastomosis healing in experimental research involving severe diabetesThe Annals of The Royal College of Surgeons of England, 2017
- Design Strategies and Applications of Tissue BioadhesivesMacromolecular Bioscience, 2012
- Fibrinolytic Proteins in Human Bile Accelerate Lysis of Plasma Clots and Induce Breakdown of Fibrin SealantsAnnals of Surgery, 2012
- Hemostats, sealants, and adhesives III: a new update as well as cost and regulatory considerations for components of the surgical toolboxTransfusion, 2012
- Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesivesActa Biomaterialia, 2011
- Hemostats, sealants, and adhesives: components of the surgical toolboxTransfusion, 2008
- Application of Fibrin Glue Sealant After Hepatectomy Does Not Seem JustifiedAnnals of Surgery, 2007
- Does fibrin glue sealant decrease the rate of pancreatic fistula after pancreaticoduodenectomy? Results of a prospective randomized trialJournal of Gastrointestinal Surgery, 2004
- Esophageal atresia—A rabbit model to study anastomotic healing and the use of tissue adhesive fibrin sealantJournal of Pediatric Surgery, 1988