Severe megaloblastic anemia: Vitamin deficiency and other causes
- 3 March 2020
- journal article
- review article
- Published by Cleveland Clinic Journal of Medicine in Cleveland Clinic Journal of Medicine
- Vol. 87 (3), 153-164
- https://doi.org/10.3949/ccjm.87a.19072
Abstract
Megaloblastic anemia causes macrocytic anemia from ineffective red blood cell production and intramedullary hemolysis. The most common causes are folate (vitamin B9) deficiency and cobalamin (vitamin B12) deficiency. Megaloblastic anemia can be diagnosed based on characteristic morphologic and laboratory findings. However, other benign and neoplastic diseases need to be considered, particularly in severe cases. Therapy involves treating the underlying cause—eg, with vitamin supplementation in cases of deficiency, or with discontinuation of a suspected medication.Keywords
This publication has 34 references indexed in Scilit:
- Laboratory assessment of folate (vitamin B9) statusJournal of Clinical Pathology, 2018
- Vitamin B12 deficiency from the perspective of a practicing hematologistBlood, 2017
- Megaloblastic AnemiasMedical Clinics of North America, 2017
- Autoimmune gastritis: Pathologist’s viewpointWorld Journal of Gastroenterology, 2015
- Diagnosis and classification of pernicious anemiaAutoimmunity Reviews, 2014
- Vitamin B12DeficiencyThe New England Journal of Medicine, 2013
- Dysplasia Has A Differential Diagnosis: Distinguishing Genuine Myelodysplastic Syndromes (MDS) From Mimics, Imitators, Copycats and ImpostorsCurrent Hematologic Malignancy Reports, 2012
- Megaloblastic Anemia and Other Causes of MacrocytosisClinical Medicine & Research, 2006
- Evaluation of macrocytosis by general practitioners.Journal of Studies on Alcohol, 1996
- Vitamin B12 absorption and malabsorption.Gut, 1989