The second rule of Amir Sher Ali Khan (1868-1878) has a special place in the contemporary history of Afghanistan. During this period, new features of the political, administrative, and cultural system were introduced, new institutions established in the country, and efforts were made to flourish civilization. He is one of the most broad-minded kings in the modern history of Afghanistan who has done his best for the development of Afghanistan. This article discusses the political, social, and cultural reforms of the second sovereignty of Amir Sher Ali Khan to create a sequence of historical events and take a chronological form, therefore, before his rule and especially during the reign of his father Amir Dost Mohammad Khan, several reform programs have been briefly discussed which the basis for his reforms are. In this article, we conclude that Amir Sher Ali Khan has brought about significant political, social, and cultural reforms for the new Afghanistan. On the other hand, he got into a series of internal problems and a big game between the Russian and British colonial circles and not allowed him to carry out all his plans. The British invaded Afghanistan for the second time and ended its rule, and whatever programs for the flourishing of a new civilization were suspended, Afghanistan was left behind in the caravan of global progress.