Factors Associated With Severe Gastrointestinal Diagnoses in Children With SARS-CoV-2 Infection or Multisystem Inflammatory Syndrome
Open Access
- 20 December 2021
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Network Open
- Vol. 4 (12), e2139974
- https://doi.org/10.1001/jamanetworkopen.2021.39974
Abstract
The gastrointestinal (GI) tract is one of the target organs affected by SARS-CoV-2. The colocalization of angiotensin-converting enzyme 2 and the proteaselike transmembrane serine protease 2, essential receptors for SARS-CoV-2 cell binding and internalization, has been noted in the human GI tract.1,2 The presence of isolated GI symptoms in some patients with SARS-CoV-2 infection, as well as the prolonged fecal shedding reported in neonates and children, supports the hypothesis of a fecal-oral transmission of SARS-CoV-2.3This publication has 30 references indexed in Scilit:
- Covid-19 may present with acute abdominal painBritish Journal of Surgery, 2020
- SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genesNature Medicine, 2020
- COVID-19: faecal–oral transmission?Nature Reviews Gastroenterology & Hepatology, 2020
- Prolonged presence of SARS-CoV-2 viral RNA in faecal samplesThe Lancet Gastroenterology & Hepatology, 2020
- Appendicitis as the presenting manifestation of Kawasaki diseasePediatric Surgery International, 2013
- World Medical Association Declaration of HelsinkiJAMA, 2013
- Routine Histopathologic Examination of Appendectomy Specimens: Retrospective Analysis of 1255 PatientsInternational Surgery, 2013
- Association of viral isolates from stool samples with intussusception in childrenInternational Journal of Infectious Diseases, 2011
- Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesisThe Journal of Pathology, 2004
- The Journal of PathologyThe Journal of Pathology, 1998