The existing phenomenological study explored the existential issues of Pakistani breast cancer women. Moderately interviews were conducted to obtain information, which were digitally recorded and transcribed. Purposive sampling technique was employed to obtain a sample. Ten breast cancer-diagnosed women were included in this research. The qualitative information was investigated using Interpretative Phenomenological Analysis. Personal Cluster and Social Cluster evolved from the statements of existential issues by breast cancer women. The clusters were further sorted into the following categories: Existential Anxiety, Death Anxiety, Meaninglessness, Hopelessness, Loneliness, Body Image Discomfort, Guilt, Loss of autonomy, Lowered Self-Esteem, Pessimistic, Abashment, Peace of Mind, Dissatisfaction, Personal Loss of Control, Mobility Loss, Personal Responsibility, Loss of Personal Identity, Loss of Personal Relationships, Demoralization, Shame, Disappointment, Loss of Female Identity, Helplessness, Dependency, Loss Freedom of Choice, Powerlessness, Rejection, Social isolation, Burden to Others, Loss of Dignity, Integrity Loss, Loss of Outdoor Mobility, Social Responsibility, Loss of Social Identity, Loss of Group Identity, Loss of Family Identity, Loss of Professional Identity, Loss of Social Relationships, Futility, Alienation, Ignorance. The findings have significance for clinical psychologists, counselors, and therapists who work in primary and secondary health care settings.