Evaluation of homocysteine levels in ischaemic heart disease proved by 2d- echocardiography

Abstract

Background & Objectives: Homocysteine is a risk factor for atherosclerotic vascular disease, with adverse influence on endothelial cells, vascular smooth muscle cells, connective tissue, interactions with plasma lipoproteins and platelets. This study was conducted to study the association between levels of homocysteine and IHD, the clinical profile of subjects in relation to their lifestyle, and the socio-demographic profile of patients with established ischaemic heart disease. Methods: The data for this study was collected from patients who presented to NRI Medical College& Hospital Chinakakani from August 2017 to August 2019. 30 cases and 30 age and sex matched controls were taken. All cases taken were proven cases of IHD proved by 2D echocardiography. Homocysteine levels were compared between the two groups and the results drawn. Results: Homocysteine levels were found to be significantly higher in cases with IHD when compared to controls. Both cases and controls with dyslipidemia and other risk factors for IHD like age above 50 years, diabetes mellitus, hypertension and a history of CVA were found to have significantly higher homocysteine levels. Interpretation & Conclusion: A significant association was found between elevated serum homocysteine levels and both IHD and risk factors for IHD even in the absence of IHD. This suggests that elevated homocysteine levels are an independent risk factor for developing IHD.