Association Between Enlarged Perivascular Spaces and Cognition in a Memory Clinic Population
- 28 June 2022
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 99 (13), e1414-e1421
- https://doi.org/10.1212/wnl.0000000000200910
Abstract
Background and Objectives Although enlarged perivascular spaces (EPVS) have been suggested as an emerging measure of small vessel disease (SVD) in the brain, their association with cognitive impairment is not yet clearly understood. We aimed to examine the relationship between each EPVS in the basal ganglia (BG-EPVS) and centrum semiovale (CSO-EPVS) with cognition in a memory clinic population. Methods Participants with a diverse cognitive spectrum were recruited from a university hospital memory clinic. They underwent comprehensive clinical and neuropsychological assessments and brain MRI. BG-EPVS and CSO-EPVS were measured on T2-weighted MRI and then dichotomized into low and high degrees for further analyses. Other SVD markers were assessed using validated rating scales. Results A total of 910 participants were included in this study. A high degree of BG-EPVS was significantly associated with poorer scores on the executive function domain, but not with other cognitive domains, when age, sex, education, MRI scanner type, and cognitive diagnosis were controlled as covariates. However, the association between BG-EPVS and executive function was no longer significant after controlling for other markers of SVD, such as lacunar infarcts and periventricular white matter hyperintensities, as additional covariates. CSO-EPVS did not have a significant relationship with any cognitive scores, regardless of the covariates. Discussion Our findings from a large memory clinic population suggest that EPVS, regardless of the topographical location, may not be used as a specific SVD marker for cognitive impairment, although an apparent association was observed between a high degree of BG-EPVS and executive dysfunction before controlling other SVD markers that share a common pathophysiologic process with BG-EPVS.Keywords
This publication has 43 references indexed in Scilit:
- Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairmentAnnals of Neurology, 2013
- Accumulation of MRI Markers of Cerebral Small Vessel Disease is Associated with Decreased Cognitive Function. A Study in First-Ever Lacunar Stroke and Hypertensive PatientsFrontiers in Aging Neuroscience, 2013
- The Rotterdam Scan Study: design and update up to 2012European Journal of Epidemiology, 2011
- Induced-hypertension in progressing lacunar infarctionJournal of the Neurological Sciences, 2011
- Severity of Dilated Virchow-Robin Spaces Is Associated With Age, Blood Pressure, and MRI Markers of Small Vessel DiseaseStroke, 2010
- Enlarged Perivascular Spaces on MRI Are a Feature of Cerebral Small Vessel DiseaseStroke, 2010
- Cerebral microbleeds: a guide to detection and interpretationThe Lancet Neurology, 2009
- A normative study of the CERAD neuropsychological assessment battery in the Korean elderlyJournal of the International Neuropsychological Society, 2004
- The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's diseaseNeurology, 1989
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984