Actuality of study the vascular endothelial growth factor in patients with arteriovenous malformation

Abstract

Objective – to determine the role of endothelial vascular growth factor (VEGF) in the formation, progression of arteriovenous malformations (AVM), the occurrence of relapses of this disease and to justify the need to study the level of VEGF in blood plasma in patients with AVM.Materials and methods. The analysis of 15 sources of scientific and medical literature on the etio-logy and pathogenesis of AVM. Recent data of studies of the role of VEGF in the formation, progression of AVM, occurrence of relapses of this disease have been systematized. The own results of the study of the level of VEGF in blood plasma in 19 patients with AVM of different localization are presented.Results. The important role of increasing the level of VEGF in the formation, progression of AVM, both according to scientific and medical literature and according to own research, has been proved. The necessity to study the level of VEGF in blood plasma in patients with AVM in the perioperative period to improve the effectiveness of complex treatment of such patients is substantiated.Conclusions. Endothelial vascular growth factor plays an important role in the formation, progression of arteriovenous malformations. Increased level of VEGF in blood plasma in patients with AVM was noted. Increased levels of VEGF in blood plasma after surgical or endovascular treatment may cause relapses of the disease. Changes in the level of VEGF in blood plasma after surgical or endovascular treatment have not been studied at present. Studying the level of VEGF in blood plasma before and after surgical and endovascular treatment opens new possibilities for the use of drugs that block the action of VEGF as a neoadjuvant therapy for the prevention of recurrence or regression of stroke.