Hybrid Phosphotungstic acid -Dopamine (PTA-DA) Like-flower Nanostructure Synthesis as a Furosemide Drug Delivery System and Kinetic Study of Drug Releasing

Abstract

The work aimed to focus on the synthesis of the ratio 1:1 from phosphotungstic acid -dopamine nano-structure in tris(hydroxymethyl)-aminomethane (Tris)- HCl solution at pH ranged 8.5-9.5. That leads to prepared a light yellow colored nanostructure powder. The SEM analysis gave reasonable shapes for this prepared nanostructure such as flower-like nanostructure. These nano compounds were used as Furosemide drug delivery, which loaded on its surface at 12h at pH about 9.5. This pH value is suitable for loading drug inside the prepared nanostructure, that attitude to the phosphotungstic acid (POM) compound is semistable in basic media, hence it opens it to bond and perminented of loading drug in basic medium (pH 9.5). The kinetic study for relasing of this drug found to be pseudo first order