The Utility of Zinc Augmentation in Diabetes - A Narrative Review
- 29 November 2021
- journal article
- review article
- Published by Sciencedomain International in Journal of Pharmaceutical Research International
- Vol. 33 (52A), 221-233
- https://doi.org/10.9734/jpri/2021/v33i52a33578
Abstract
Diabetes mellitus has sadly become a pandemic, with chronic and debilitating complications which by far are more pronounced in the developing countries of the world. Despite the availability of a wide array of anti-diabetic drugs (both oral and parenteral medications), micro-vascular and macro-vascular diabetes complications are still common. Owing to this sad reality, the place of micronutrients augmentation has come to the frontline of research in diabetes management. Zinc is one of the well-known micro-elements with diverse functions in various physiologic processes in humans. The authors reviewed the role of zinc augmentation in subjects with diabetes generally, both those with complications of diabetes and those without complications. Emphasis was also laid on the modulatory actions of zinc on various diabetes-related processes which include: its anti-oxidant effect; improvement of insulin secretion/sensitivity; increased amylin action; inhibition of gluconeogenesis and atherosclerosis. The impact of zinc supplementation on fasting plasma glucose, glycated haemoglobin and lipid indices were also detailed, while a brief overview of the pharmacology and pharmacokinetics of zinc was also undertaken.Keywords
This publication has 58 references indexed in Scilit:
- Zinc and Diabetic RetinopathyJournal of Diabetes Research, 2013
- Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysisDiabetology & Metabolic Syndrome, 2012
- Role of Zinc in Human Islet Amyloid Polypeptide AggregationJournal of the American Chemical Society, 2010
- Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agentThe American Journal of Clinical Nutrition, 2010
- Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretionDiabetologia, 2010
- The Essential Toxin: Impact of Zinc on Human HealthInternational Journal of Environmental Research and Public Health, 2010
- From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes MellitusDiabetes, 2009
- MG53 nucleates assembly of cell membrane repair machineryNature, 2008
- Serum Zinc Level and Coronary Heart Disease Events in Patients With Type 2 DiabetesDiabetes Care, 2007
- Intranasal Zinc and Anosmia: The Zinc‐Induced Anosmia SyndromeThe Laryngoscope, 2006