Synthesis of new 5-aryl tetrazoline and evaluation of their antifungal and antibacterial activity

Abstract

The research resulted in the production of new tetrazoline derivatives. Firstly; the reaction of N-acetyl chloro cyclic imides with hydrazine hydrate to give compounds (1,2). Then, compounds (1,2) were reacted with different aromatic aldehydes to give Schiff bases (3-10). The compounds of N-( 2-chloro acetyl) cyclic imides were reacted with sodium azide to give N-(azido acetyl) cyclic imides (11,12). Finally, the reaction of the prepared Schiff bases compounds with azide compounds and cyclization to gave 5-aryl tetrazoline on cyclic imides (13-20). The prepared compounds were characterized by Fourier transform infrared spectroscopy (FT-IR) and some of them byProton nuclear magnetic resonance (1H-NMR), melting point, and were studied the effects of the preparing compounds on some strains of bacteria and fungi.