Approach to Searching for the Producers of Antibiotics That Overcome Drug Resistance of Microorganisms
- 21 October 2021
- journal article
- Published by Publishing House OKI in Antibiotics and Chemotherapy
- Vol. 66 (7-8), 4-12
- https://doi.org/10.37489/0235-2990-2021-66-7-8-4-12
Abstract
Currently, the problem of antibiotic resistance of opportunistic and pathogenic microorganisms is extremely urgent. In order to find new effective natural antibiotics, it is necessary to intensify the search process. In the gradual selection of the most promising producers, we introduced the stage of determining the antibiotic activity of the culture fluid of the studied natural strains against the clinical isolates of hospital microorganisms with multiple resistance to medical antibiotics. Determining the species affiliation of potential producers allows to select those producers of a particular species that differ in the antimicrobial spectrum of activity from those described in the literature. Four strains of actinomycetes that showed activity against resistant clinical isolates of yeast Candida albicans, C.famata, C.parapsilosis and Cryptococcus neoformans were selected, namely: Nocardia soli INA 01217, Streptomyces bottropensis INA 01214, S.chromofuscus INA 01211 and S.netropsis INA 01190. The N.soli INA 01217 strain also shows antibiotic activity against the Gram-negative bacterium Escherichia coli ATCC 25922. These strains of actinobacterial producers were selected for subsequent chemical studies of the antimicrobial compounds formed by them.Keywords
This publication has 31 references indexed in Scilit:
- Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanusMarine Drugs, 2012
- Characterization of the Biosynthesis Gene Cluster for the Pyrrole Polyether Antibiotic Calcimycin (A23187) in Streptomyces chartreusis NRRL 3882Antimicrobial Agents and Chemotherapy, 2011
- Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of AmericaClinical Infectious Diseases, 2009
- Marcel Faber Roundtable: Is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?Journal of Industrial Microbiology & Biotechnology, 2006
- Bioactive Microbial MetabolitesThe Journal of Antibiotics, 2005
- Actinomycin. Chemistry and mechanism of actionChemical Reviews, 1974
- Stoffwechselprodukte von Mikroorganismen. 57. Mitteilung. BoromycinHelvetica Chimica Acta, 1967
- Bottromycin. I. A New Sulfur-containing AntibioticJournal of the American Chemical Society, 1957
- Chartreusin, a New Antibiotic Produced by Streptomyces chartreusis, a New SpeciesJournal of the American Chemical Society, 1953
- Netropsin, a New Antibiotic Produced by a StreptomycesJournal of the American Chemical Society, 1951