New Search

Export article
Open Access

Determination of Critical Influencing Factor on pH Stability of Yuxingcao Injection

Xianjun Long, Bo Liu, Zuren Peng, Ping Qiu, Xuechun Yang, Yuanxiang Yang, Meili Wang, Songmao Yin, Xingchu Gong
Pharmacology & Pharmacy , Volume 11, pp 188-195; doi:10.4236/pp.2020.118017

Abstract: The change of drug quality of Yuxingcao injection after formulation is considered as one of the causes for adverse reactions. In this study, orthogonal experimental design was used to investigate the influencing factors on the pH stability of Yuxingcao injection. Two methods of accelerated tests were carried out in the experiments. The results showed that using Tween 80 as the solubilizer could significantly decrease the pH value of Yuxingcao injection after accelerated tests. There was no significant difference in the pH value after the accelerated tests when the other 6 factors varied, including the type of liquid processed, the dosage of activated carbon, heating temperature, reagents for pH adjustment, pH value range after adjustment, and sterilization conditions. In order to improve the quality stability of Yuxingcao injection, the quality of Tween 80 should be strictly controlled to minimize the change of pH value of Yuxingcao injection.
Keywords: Tween 80 / Chinese Medicine Injection / Quality Stability / Houttuyniae Herba

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

Share this article

Click here to see the statistics on "Pharmacology & Pharmacy" .
Back to Top Top