Cyclophosphamide for the Treatment of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition
- 1 January 2021
- journal article
- research article
- Published by Medknow in Saudi Journal of Kidney Diseases and Transplantation
- Vol. 32 (4), 1166-1170
- https://doi.org/10.4103/1319-2442.338293
Abstract
About 3% of the population aged more than 50 years, is affected by monoclonal gammopathy of undetermined significance (MGUS), a premalignant condition that may progress to lymphoproliferative disorders. Since MGUS does not represent the diseases associated with end organ damage, a new term, monoclonal gammopathy of renal significance (MGRS) is coined for the monoclonal gammopathies that are associated with renal disorders. MGRS is classified into various types, including monoclonal immunoglobulin deposition disease (MIDD) and proliferative glomerulonephritis with monoclonal immunoglobulin deposition (PGNMID). PGNMID presents with membranoproliferative glomerulonephritis-type lesions associated with immunoglobulin deposition. This disease entity has a poor prognosis and its optimum treatment is yet to be established. We present the case of an elderly male, a known patient of light chain deposition disease, a form of MIDD, who initially lost to follow-up but later presented with PGNMID, wherein he was treated with steroid and cyclophosphamide, to which he responded.Keywords
This publication has 12 references indexed in Scilit:
- Successful management of proliferative glomerulonephritis with monoclonal immune deposits with combined immunosuppressive therapyBMJ Case Reports, 2018
- Proliferative Glomerulonephritis With Masked Monoclonal Deposits Responsive to Myeloma TherapyKidney International Reports, 2017
- Successful treatment with bortezomib and dexamethasone for proliferative glomerulonephritis with monoclonal IgG deposits in multiple myeloma: a case reportBMC Nephrology, 2017
- Paraprotein–Related Kidney Disease: Glomerular Diseases Associated with ParaproteinemiasClinical Journal of the American Society of Nephrology, 2016
- Proliferative glomerulonephritis associated with monoclonal immune deposits: A case report and review of literatureIndian Journal of Nephrology, 2014
- Monoclonal Gammopathy–Associated Proliferative GlomerulonephritisMayo Clinic Proceedings, 2013
- Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificantBlood, 2012
- Proliferative Glomerulonephritis with Monoclonal IgG Deposits Recurs in the AllograftClinical Journal of the American Society of Nephrology, 2011
- Membranoproliferative Glomerulonephritis Secondary to Monoclonal GammopathyClinical Journal of the American Society of Nephrology, 2010
- A Case of Atypical Light Chain Deposition Disease—Diagnosis and TreatmentClinical Journal of the American Society of Nephrology, 2007