Simple Markers for Subclinical Inflammation in Patients with Familial Mediterranean Fever
Open Access
- 1 January 2015
- journal article
- Published by International Scientific Information, Inc. in Medical Science Monitor
- Vol. 21, 298-303
- https://doi.org/10.12659/msm.892289
Abstract
In this study we investigated the potential of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV), and red cell width distribution (RDW) as new inflammatory markers to identify chronic inflammations during symptom-free periods in children diagnosed with Familial Mediterranean Fever (FMF). The study included 153 children diagnosed with FMF based on the Tel-Hashomer Criteria, and 90 healthy volunteers. Hospital records were obtained to collect NLR, PLR, MPV, RDW, and FMF scores and the FMF mutation analyses of the patients enrolled in the study. Data on proteinuria were also collected and defined as a protein/creatinine ratio >0.2. NLR, PLR, MPV, and RDW were significantly higher in symptom-free FMF patients than in the control group. C-reactive protein values also weakly correlated with NLR, PLR, MPV, and RDW, but the correlation was not statistically significant. NLR had the strongest correlation with CRP. The NLR cut-off point to indicate subclinical inflammation in symptom-free FMF patients was calculated to be 1.65. NLR, PLR, MPV, and RDW are potential subclinical inflammation markers in patients with FMF. NLR, PLR, MPV, and RDW values are higher in patients with FMF during symptom-free periods. NLR was found to be the most reliable marker for subclinical inflammation when compared to PLR, MPV, and RDW. We also found that these markers are not significantly higher in proteinuric patients when compared with levels in non-proteinuric patients.This publication has 37 references indexed in Scilit:
- Platelet-to-Lymphocyte Ratio: One of the novel and valuable platelet indices in hemodialysis patientsHemodialysis International, 2013
- Is Neutrophil/Lymphocyte Ratio Associated with Subclinical Inflammation and Amyloidosis in Patients with Familial Mediterranean Fever?BioMed Research International, 2013
- Neutrophil–Lymphocyte Ratio and the Platelet–Lymphocyte Ratio Predict the Limb Survival in Critical Limb IschemiaClinical and Applied Thrombosis/hemostasis, 2013
- Increased Levels of Macrophage Migration Inhibitory Factor in Patients with Familial Mediterranean FeverInternational Journal of Medical Sciences, 2013
- The Relationship between Oxidative Stress, Inflammation, and Atherosclerosis in Renal Transplant and End-Stage Renal Disease PatientsRenal Failure, 2012
- Renal amyloidosis in childrenPediatric Nephrology, 2011
- Chronic inflammation in FMF: markers, risk factors, outcomes and therapyNature Reviews Rheumatology, 2010
- Serum antioxidants and inflammation predict red cell distribution width in older women: The Women's Health and Aging Study IClinical Nutrition, 2010
- Role of Gender in the Associations of Microalbuminuria with Inflammatory Markers in Hypertensive Subjects: A Cross-Sectional StudyKidney and Blood Pressure Research, 2009
- Serum sIL-2r, IL-6, IL-10 and TNF-? level in familial Mediterranean fever patientsClinical Rheumatology, 2003