Serum cystatin C is an early renal dysfunction biomarker in patients with hepatitis C virus
Open Access
- 24 November 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in Egyptian Liver Journal
- Vol. 12 (1), 1-8
- https://doi.org/10.1186/s43066-022-00231-x
Abstract
Hepatitis C virus (HCV) may induce extrahepatic manifestations as acute or chronic renal dysfunction. The aim was to evaluate the diagnostic role of some biomarkers as cystatin C, cryoglobulins, rheumatoid factor (RF), and complement C3 for extrahepatic renal affection in newly diagnosed patients with HCV infection. Blood and urine were collected from randomized individuals screened for new HCV infection (n=400). The studied populations were divided into 3 groups: control group I: thirty healthy individuals not suffering from either liver or kidney diseases, group IIa: thirty HCV patients who have positive HCV antibody test but showed negative PCR test, and group IIb: thirty HCV patients who showed positive results for both HCV antibody and PCR tests. In HCV group IIb, levels of serum total bilirubin, AST and ALT, and urine albumin/creatinine ratio were increased whereas serum albumin and creatinine clearance were decreased versus other groups. However, the levels of blood urea nitrogen and serum creatinine were still within the normal range in all groups. In HCV group IIb, cystatin C, cryoglobulins, and RF levels were increased; meanwhile, serum creatinine/cystatin C ratio and complement 3 levels were decreased compared to the other groups. HCV-infected patients significantly had higher serum cystatin C (>1.24 mg/L, PP=0.002), and cystatin C was significantly correlated with liver and kidney parameters. High serum cystatin C and low creatinine/cystatin C ratio may be early indicators of mild renal dysfunction with normal serum levels of creatinine in HCV-infected individuals.Keywords
This publication has 49 references indexed in Scilit:
- Hepatitis C Virus Suppresses C9 Complement Synthesis and Impairs Membrane Attack Complex FunctionJournal of Virology, 2013
- Evaluation of serum creatinine- and cystatin C-based equations for the estimation of glomerular filtration rate in a Chinese populationScandinavian Journal of Urology and Nephrology, 2012
- Hepatitis C Virus Proteins Inhibit C3 Complement ProductionJournal of Virology, 2012
- Changes in dietary protein intake has no effect on serum cystatin C levels independent of the glomerular filtration rateKidney International, 2011
- Complement: a key system for immune surveillance and homeostasisNature Immunology, 2010
- Clinical and Morphologic Spectrum of Renal Involvement in Patients With Mixed Cryoglobulinemia Without Evidence of Hepatitis C Virus InfectionMedicine, 2009
- Multicenter Study on Hepatitis C Virus–Related Cryoglobulinemic GlomerulonephritisAmerican Journal of Kidney Diseases, 2007
- Assessing Kidney Function — Measured and Estimated Glomerular Filtration RateThe New England Journal of Medicine, 2006
- Increased cystatin C serum concentrations in patients with hepatic diseases of various severitiesClinica Chimica Acta; International Journal of Clinical Chemistry, 2004
- High incidence of hepatitis C virus infection in patients with cryoglobulinemic neuropathyAnnals of Neurology, 1993