The Ratios of Triglycerides and C-reactive protein to High density-lipoprotein -cholesterol as valid biochemical markers of the Nascent Metabolic Syndrome
- 3 June 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in Endocrine Research
- Vol. 46 (4), 196-202
- https://doi.org/10.1080/07435800.2021.1930039
Abstract
Aims: Metabolic syndrome (MetS), a cardiometabolic cluster, is a major global problem. The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) is a good biomarker of MetS in certain populations C-reactive protein (CRP) has also been also shown to be a biomarker of MetS. Since CRP captures inflammation, we compared the ratios of TG to HDL-C and CRP to HDL-C in patients with nascent MetS. Methods: Patients with MetS (n = 58) and matched controls (n = 44) were recruited. Fasting blood samples were obtained for routine laboratories, insulin, and adipokines. TG and CRP ratios to HDL-C were calculated. Data were analyzed statistically. Results: Both the TG to HDL-C and CRP to HDL-C ratios were significantly increased in MetS and both increased with increasing severity of MetS. Whilst both correlated with cardiometabolic features and insulin resistance, only the CRP to HDL-C ratio correlated significantly with adiponectin and leptin. Receiver operating characteristic curve analysis showed that both ratios showed excellent discrimination for MetS with no significant differences between ratios. Conclusions: Thus both the TG to HDL-C and CRP to HDL-C ratios are significantly increased in patients with nascent MetS and appear to be valid biomarkers of MetS. However, these preliminary findings with CRP: HDL-C need confirmation in large prospective studies and could have important implications for assessing cardiometabolic risk in African Americans, an under-served population.Keywords
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This publication has 37 references indexed in Scilit:
- Increased Toll-Like Receptor Activity in Patients With Metabolic SyndromeDiabetes Care, 2012
- Adipose Tissue Dysregulation in Patients with Metabolic SyndromeJournal of Clinical Endocrinology & Metabolism, 2011
- Diagnosis of the Metabolic Syndrome Is Associated With Disproportionately High Levels of High-Sensitivity C-Reactive Protein in Non–Hispanic Black AdolescentsDiabetes Care, 2011
- The Triglyceride/High-Density Lipoprotein Cholesterol Ratio Fails to Predict Insulin Resistance in African-American Women: An Analysis of Jackson Heart StudyMetabolic Syndrome and Related Disorders, 2010
- Harmonizing the Metabolic SyndromeJournal of the American College of Cardiology, 2009
- Human C-reactive protein and the metabolic syndromeCurrent Opinion in Lipidology, 2009
- Comparison of Serum Lipid Values in Subjects With and Without the Metabolic SyndromeThe American Journal of Cardiology, 2008
- CRP and Adiponectin and Its Oligomers in the Metabolic SyndromeAmerican Journal of Clinical Pathology, 2008
- Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race/ethnicity?Cardiovascular Diabetology, 2008
- Is There a Simple Way to Identify Insulin-Resistant Individuals at Increased Risk of Cardiovascular Disease?The American Journal of Cardiology, 2005