Effects of Remote Ischemic Conditioning on Cerebral Hemodynamics in Ischemic Stroke
Open Access
- 1 January 2020
- journal article
- review article
- Published by Taylor & Francis Ltd in Neuropsychiatric Disease and Treatment
- Vol. ume 16, 283-299
- https://doi.org/10.2147/ndt.s231944
Abstract
Ischemic stroke is one of the most common cerebrovascular diseases and is the leading cause of disability all over the world. It is well known that cerebral blood flow (CBF) is disturbed or even disrupted when ischemic stroke happens. The imbalance between demand and shortage of blood supply makes ischemic stroke take place or worsen. The search for treatments that can preserve CBF, especially during the acute phase of ischemic stroke, has become a research hotspot. Animal and clinical experiments have proven that remote ischemic conditioning (RIC) is a beneficial therapeutic strategy for the treatment of ischemic stroke. However, the mechanism by which RIC affects CBF has not been fully understood. This review aims to discuss several possible mechanisms of RIC on the cerebral hemodynamics in ischemic stroke, such as the improvement of cardiac function and collateral circulation of cerebral vessels, the protection of neurovascular units, the formation of gas molecules, the effect on the function of vascular endothelial cells and the nervous system. RIC has the potential to become a therapeutic treatment to improve CBF in ischemic stroke. Future studies are needed to highlight our understanding of RIC as well as accelerate its clinical translation.Keywords
This publication has 124 references indexed in Scilit:
- Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signalingProceedings of the National Academy of Sciences of the United States of America, 2012
- The Chronic Protective Effects of Limb Remote Preconditioning and the Underlying Mechanisms Involved in Inflammatory Factors in Rat StrokePLOS ONE, 2012
- Protective Effect of Delayed Remote Limb Ischemic Postconditioning: Role of Mitochondrial KATP Channels in a Rat Model of Focal Cerebral Ischemic Reperfusion InjuryJournal of Cerebral Blood Flow & Metabolism, 2012
- Carbon Monoxide–Activated Nrf2 Pathway Leads to Protection Against Permanent Focal Cerebral IschemiaStroke, 2011
- Hydrogen sulfide is an endogenous stimulator of angiogenesisProceedings of the National Academy of Sciences of the United States of America, 2009
- Limb remote ischemic postconditioning protects against focal ischemia in ratsBrain Research, 2009
- Inflammation and the neurovascular unit in the setting of focal cerebral ischemiaNeuroscience, 2009
- H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-LyaseScience, 2008
- Limb remote-preconditioning protects against focal ischemia in rats and contradicts the dogma of therapeutic time windows for preconditioningNeuroscience, 2008
- Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculationNature Neuroscience, 2002