New Mechanistic Insights of Melasma
Open Access
- 1 February 2023
- journal article
- review article
- Published by Taylor & Francis Ltd in Clinical, Cosmetic and Investigational Dermatology
- Vol. ume 16, 429-442
- https://doi.org/10.2147/ccid.s396272
Abstract
Melasma is a common acquired disorder of pigmentation that negatively impacts quality of life. Present treatments show poor therapeutic effect with frequent recurrence. This in large part is due to the currently limited understanding of the disease’s etiology. It is urgent to elucidate the pathogenesis of melasma to further the discovery of new therapeutic strategies. Recent studies show that melasma is triggered or aggravated by a variety of factors, including genetic susceptibility, ultraviolet radiation, and sex hormone dysregulation. Ultraviolet B radiation upregulates the expression of several melanocyte-specific genes and stimulates the release of key factors that participate in the synthesis of melanin. There is a significant increase in melanin in both the epidermal and dermal layers of affected skin, possibly due to abnormalities in crosstalk between the melanocytes and other cells. Melanogenesis is regulated through various signaling networks including the Wnt/β-catenin, PI3K/Akt, cAMP/PKA, and SCF/c-kit-mediated signaling pathways. In addition, inflammatory mediators, oxidative stress, neuroactive molecules, sebocytes, etc, have also been proved to be related to the pathogenesis of melasma. This review provides a comprehensive update on the current understanding of the pathogenesis of melasma.Keywords
This publication has 80 references indexed in Scilit:
- Risk factors for facial melasma in women: a case–control studyBritish Journal of Dermatology, 2014
- Reduced MiR-675 in Exosome in H19 RNA-Related Melanogenesis via MITF as a Direct TargetJournal of Investigative Dermatology, 2014
- Changes in nuclear morphology and chromatin texture of basal keratinocytes in melasmaJournal of the European Academy of Dermatology and Venereology, 2014
- Epidemiology of melasma in Brazilian patients: a multicenter studyInternational Journal of Dermatology, 2013
- The Association Between Melasma and Postinflammatory Hyperpigmentation in Acne PatientsIranian Red Crescent Medical Journal, 2013
- Reduced WIF-1 Expression Stimulates Skin Hyperpigmentation in Patients with MelasmaJournal of Investigative Dermatology, 2013
- PDZK1 Upregulation in Estrogen-Related Hyperpigmentation in MelasmaJournal of Investigative Dermatology, 2012
- Solar ultraviolet radiation induces biological alterations in human skin in vitro: Relevance of a well-balanced UVA/UVB protectionIndian Journal of Dermatology, Venereology and Leprology, 2012
- Transcriptional Profiling Shows Altered Expression of Wnt Pathway– and Lipid Metabolism–Related Genes as Well as Melanogenesis-Related Genes in MelasmaJournal of Investigative Dermatology, 2011
- H19 RNA downregulation stimulated melanogenesis in melasmaPigment Cell & Melanoma Research, 2009