Consecutive and Selective Double Methylene Insertion of Lithium Carbenoids to Isothiocyanates: A Direct Assembly of Four‐Membered Sulfur‐Containing Cycles
Open Access
- 17 September 2021
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 60 (47), 24854-24858
- https://doi.org/10.1002/anie.202110641
Abstract
A formal CH 2 -CH 2 homologation conducted with C1 carbenoids on a carbon electrophile for the obtainment of a four-membered cycle is reported. The logic proposes the consecutive delivery of two single nucleophilic CH 2 units to an isothiocyanate – as competent electrophilic partner – resulting in the assembling of a rare imino-thietane cluster. The single synthetic operation procedure documents genuine chemocontrol, as indicated by the tolerance to various reactive elements decorating the starting materials. Significantly, the double homologation protocol is accomplished directly on a carbon electrophile, thus not requiring the installation of heteroatom-centered manifolds ( e.g. boron).This publication has 76 references indexed in Scilit:
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