Exploring a new method for the assessment of metal exposure by analysis of exhaled breath of welders
Open Access
- 23 January 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in Internationales Archiv für Arbeitsmedizin
- Vol. 95 (6), 1255-1265
- https://doi.org/10.1007/s00420-022-01833-z
Abstract
Purpose Air monitoring has been the accepted exposure assessment of toxic metals from, e.g., welding, but a method characterizing the actual dose delivered to the lungs would be preferable. Sampling of particles in exhaled breath can be used for the biomonitoring of both endogenous biomarkers and markers of exposure. We have explored a new method for the sampling of metals in exhaled breath from the small airways in a study on welders. Methods Our method for particle sampling, Particles in Exhaled Air (PExA®), is based on particle counting and inertial impaction. We applied it on 19 stainless steel welders before and after a workday. In parallel, air monitoring of chromium, manganese and nickel was performed as well as blood sampling after work. Results Despite substantial exposure to welding fumes, we were unable to show any significant change in the metal content of exhaled particles after, compared with before, exposure. However, the significance might be obscured by a substantial analytical background noise, due to metal background in the sampling media and possible contamination during sampling, as an increase in the median metal contents were indicated. Conclusions If efforts to reduce background and contamination are successful, the PExA® method could be an important tool in the investigations of metals in exhaled breath, as the method collects particles from the small airways in contrast to other methods. In this paper, we discuss the discrepancy between our findings and results from studies, using the exhaled breath condensate (EBC) methodology.Keywords
Funding Information
- Swedish Heart-Lung Foundation (254212008)
- Svenska Forskningsrådet Formas (254212006)
- University of Gothenburg
This publication has 53 references indexed in Scilit:
- Increased metal concentrations in exhaled breath condensate of industrial weldersJournal of Environmental Monitoring, 2010
- Deposition and biokinetics of inhaled nanoparticlesParticle and Fibre Toxicology, 2010
- The Mechanism of Breath Aerosol FormationJournal of Aerosol Medicine and Pulmonary Drug Delivery, 2009
- Dosimetry and toxicology of inhaled ultrafine particlesBiomarkers, 2009
- Detection of occult lung impairment in welders by induced sputum particles and breath oxidationAmerican Journal of Industrial Medicine, 2008
- Quantitative Assessment and Repeatability of Chlorine in Exhaled Breath CondensateRespiration, 2005
- Standardisation of spirometryEuropean Respiratory Journal, 2005
- Origin of nitrite and nitrate in nasal and exhaled breath condensate and relation to nitric oxide formationThorax, 2005
- The influence of operating parameters on number-weighted aerosol size distribution generated from a gas metal arc welding processJournal of Aerosol Science, 2002
- Factors influencing breath condensate volumePneumologie, 2001