Anemia is a group of diseases described by decrease in hemoglobin or red blood cells, resulting in decreased oxygen-carrying capacity of blood. Iron deficiency is the most frequent nutritional deficiency, and the most routine cause of nutrition related anemia. Vitamin B12 deficiency is the sequence of impaired absorption (pernicious anemia are imperfect production of intrinsic factor compulsory for absorption of vitamin B 12). Without folic acid, deoxyribonucleic duplication and cell separation cannot continue. Colchicine, para-aminosalicylic acid and heavy alcohol intake for lengthy than 2 weeks perhaps generates malabsorption of vitamin B12. Iron combines with porphyrin and globin chains to figure hemoglobin, which is underpinning for oxygen release from the lungs to different tissues. Folic acid should not be given alone in patients with pernicioius anemia without knowing whether they also have a Vitamin B12 deficiency.