First Isolation of Yarrowia lipolytica in a Granulomatous Pneumonia of a Spectacled Caiman, Caiman crocodilus Linnaeus, 1758
Open Access
- 28 October 2022
- Vol. 11 (11), 1255
- https://doi.org/10.3390/pathogens11111255
Abstract
Contrary to humans, candidiasis is a rare infection in animals. However, in reptiles, candidiasis can cause gastrointestinal, cutaneous, or rarely systemic infections in stressed animals. The infections due to Yarrowia lipolytica have been increasingly described in human medicine, and hundreds of cases are reported, comprised of granulomatous lung lesions. Herein, granulomatous pneumonia of a spectacled caiman, Caiman crocodilus, was described, and the presence of Y. lipolytica in the lesion was confirmed through histopathology, microbiologic cultures, and molecular methods. The cause of death of the spectacled caiman was ascribed to bacterial shock septicemia consequentially to a traumatic lesion. However, in the right lung, several nodules containing white exudate were evidenced. At mycological and molecular analyses, Y. lipolytica was evidenced, and the histological finding confirmed the presence of a Candida infection in the lung granulomatous lesions. The comparison of ITS sequences with 11 Yarrowia spp. isolates, recently described in green sea turtles, and with a human strain was conducted, and the whole genome of a strain isolated in the spectacled caiman was sequenced. Even though Y. lipolytica is considered a non-pathogenic yeast and has been rarely described in animals, it seems to cause granulomatous lesions in reptiles as in humans.This publication has 53 references indexed in Scilit:
- SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell SequencingJournal of Computational Biology, 2012
- Effect of pre-weaning concentrate supplementation on peripheral distribution of leukocytes, functional activity of neutrophils, acute phase protein and behavioural responses of abruptly weaned and housed beef calvesBMC Veterinary Research, 2012
- Systemic candidiasis in farm-reared red-legged partridges (Alectoris rufa) caused by Leucosporidium sppBMC Veterinary Research, 2012
- Screening of a thiamine-auxotrophic yeast for α-ketoglutaric acid overproductionLetters in Applied Microbiology, 2010
- Sequence-Based Identification of Filamentous Basidiomycetous Fungi from Clinical Specimens: a Cautionary NoteJournal of Clinical Microbiology, 2010
- DNA–DNA hybridization values and their relationship to whole-genome sequence similaritiesInternational Journal of Systematic and Evolutionary Microbiology, 2007
- Mycological examinations on the fungal flora of the chicken combMycoses, 2005
- Multiple Sequence Alignment Using ClustalW and ClustalXCurrent Protocols in Bioinformatics, 2002
- Comparison of different strains of the yeastYarrowia lipolytica for citric acid production from glucose hydrolApplied Biochemistry and Biotechnology, 1991
- Genetic studies on the yeastSaccharomycopsis lipolytica Inactivation and mutagenesisJournal of Basic Microbiology, 1983