Polymorphisms of IL-17A and IL-17F in Periodontal Disease: A Case-Control Study
Open Access
- 22 February 2019
- journal article
- Published by Perio J
- Vol. 3 (1), 29-37
- https://doi.org/10.26810/perioj.2019.a4
Abstract
Background: Increased interleukin-17 (IL-17) leads to the production of proinflammatory mediators and increases local inflammation. Interleukin-17 may also promote receptor activator of nuclear factor kappa-B ligand (RANKL) expression on gingival fibroblasts, T cells, and B cells, resulting in alveolar bone resorption. Interleukin-17A and IL-17F levels in saliva and gingival crevicular fluid (GCF), were found to be elevated in periodontitis patients. Thus, IL-17A and IL-17F polymorphisms were hypothesized to be associated with a risk of periodontitis. Methods: The present study was conducted on 60 subjects, including 20 stage II grade B periodontitis patients, 20 stage III grade C periodontitis patients, and 20 healthy controls. Blood samples were drawn from the subjects and analyzed for IL-17A G-197A and IL-17F 7488T/C genetic polymorphisms using the TaqMan assay. Results: There was a significant statistical difference between the distribution of the different genotypes and the different alleles in the three groups for IL-17A G-197A with the A allele presence indicating a risk of periodontitis. Conclusions: Interleukin-17A G-197A polymorphism is significantly associated with different clinical forms of periodontitis in the Egyptian population. The A allele could be considered a risk factor for periodontal diseases.Keywords
This publication has 33 references indexed in Scilit:
- Effect of IL-17A blockade with secukinumab in autoimmune diseasesAnnals Of The Rheumatic Diseases, 2012
- Association between Polymorphisms in Interleukin-17A and -17F Genes and Chronic Periodontal DiseaseMediators of Inflammation, 2012
- Effect of non-surgical periodontal therapy on the levels of Th17/Th1/Th2 cytokines and their transcription factors in Chinese chronic periodontitis patientsJournal of Clinical Periodontology, 2011
- Over‐expression of forkhead box P3 and its association with receptor activator of nuclear factor‐κ B ligand, interleukin (IL) ‐17, IL‐10 and transforming growth factor‐β during the progression of chronic periodontitisJournal of Clinical Periodontology, 2009
- Association analysis of the interleukin 17A gene in Caucasian rheumatoid arthritis patients from Norway and New ZealandRheumatology, 2009
- Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal diseaseClinica Chimica Acta; International Journal of Clinical Chemistry, 2008
- Cytokine gene polymorphisms in periodontal disease: a meta‐analysis of 53 studies including 4178 cases and 4590 controlsJournal of Clinical Periodontology, 2008
- Association of tumor necrosis factor receptor type 2 +587 gene polymorphism with severe chronic periodontitisJournal of Clinical Periodontology, 2004
- Errors in the clinical assessment of periodontal destructionJournal of Periodontal Research, 1967
- Periodontal Disease in Pregnancy II. Correlation Between Oral Hygiene and Periodontal ConditionActa Odontologica Scandinavica, 1964