Lipomas are common benign soft tissue tumors which can be seen in many parts of the body, but they are uncommon in axillary region. Axilla is a rare region for lipoma. although lipoma is the most common benign mesenchymal tumor, its location in some regions are uncommon [1]. Moreover, huge and giant lipoma are uncommon. Therefore, axillary giant cell lipoma is rare presentation [2]. Lipomas are seen in subcutaneous tissue of extremities, trunk and neck commonly. Their existence in axillary region is rare. Giant lipoma in adults are 10*10 cm in diameter [3]. Lipomas are originated from mesenchymal fibrofatty tissue. Their usual presentations are soft mass without tenderness which grows slowly [4]. The most common site for location of lipoma is shoulder and back of trunk, and the second common site is head and neck [5]. Lipoma can be seen in GI tract, especially in the colonic wall [6]. Intra osseous primary lipoma is as rare as 0.1% of bone tumors. The most age of such tumor’ s presentation is in 4th decades of life. They are 70% located in the lower extremity [7]. In this case presentation we reported a ten months’ boy who was referred in our hospital due to a large and fast-growing soft tissue mass in his axilla. His arm was in 45-degree angle with the chest wall in upright position of the baby due to the huge mass. The patient was normal in physical examination except a huge and firm mass in right axilla. He had no history of any underlying disease. We found no history of such condition in his family members. Surgical excision of mass was done successfully, and Pathologic findings were mature adipose tissue compatible with lipoma.