Background: Multi-detector line CT (MDCT) has converted CT from the cross-sectional into a fully three-dimensional image.MDCT scans quickly acquire multiple thin axial images, as well as more precise images of rebuilding. Objectives: To assess the task of multislice CT diagnosis in jaw lesions with various software programmes. Patients and methods: A prospective cohort study included 50 patients with jaw swelling had been examined by multislice CT Radiodiagnosis Department, Sohag University. Results: ROC curve showed that the area under the curve of multislice CT for diagnosis of jaw swelling is 0.835, sensitivity 92.2%, specificity 89%, PPV 69.8%, NPV 87%, and accuracy is 94.5%. Conclusion: MDCT has a key role in giving an appropriate diagnosis, rating it and then directing care decisions being far superior to traditional radiography of mandible.