Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism
Open Access
- 9 September 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
Abstract
Immunity and metabolism are interdependent and coordinated, which are the core mechanisms for the body to maintain homeostasis. In tumor immunology research, immunometabolism has been a research hotspot and has achieved groundbreaking changes in recent years. However, in the field of maternal-fetal medicine, research on immunometabolism is still lagging. Reports directly investigating the roles of immunometabolism in the endometrial microenvironment and regulation of maternal-fetal immune tolerance are relatively few. This review highlights the leading techniques used to study immunometabolism and their development, the immune cells at the maternal-fetal interface and their metabolic features required for the implementation of their functions, explores the interaction between immunometabolism and pregnancy regulation based on little evidence and clues, and attempts to propose some new research directions and perspectives.Funding Information
- National Key Research and Development Program of China (2018YFC1004601, 2018YFC1003900/04)
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China (81801540)
- Natural Science Foundation of Shenzhen City (JCYJ20190813161801676)
This publication has 148 references indexed in Scilit:
- Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunityNature Immunology, 2013
- Mast cells rescue implantation defects caused by c-kit deficiencyCell Death & Disease, 2013
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory DevelopmentImmunity, 2012
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1Cell, 2011
- Complement Activation Triggers Metalloproteinases Release Inducing Cervical Remodeling and Preterm Birth in MiceThe American Journal of Pathology, 2011
- The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2Nature Immunology, 2011
- mTOR regulates memory CD8 T-cell differentiationNature, 2009
- Enhancing CD8 T-cell memory by modulating fatty acid metabolismNature, 2009
- The genetic and evolutionary balances in human NK cell receptor diversitySeminars in Immunology, 2008
- Orchestrating the orchestrators: chemokines in control of T cell trafficNature Immunology, 2008