目的：探讨右向左分流(right-to-left shunt, RLS)相关隐源性脑卒中(cryptogenic stroke, CS)患者的临床特点及引起卒中的可能机制。方法：收集2018年10月至2020年9月于我院神经内科住院并根据TOAST (Trial of Org 10172 in Acute Stroke Treatment)分型诊断为CS的患者。所有CS患者均行经颅多普勒发泡试验检查，根据有无RLS，分为RLS+组和RLS−组。比较两组人口学特征、脑血管病危险因素、血小板及凝血功能，心脏的结构与功能等方面的特点。结果：共纳入111例CS患者，RLS+组55例，RLS−组56例。血管病危险因素方面，RLS+组高血压、糖尿病及高血脂比例更少(P Objective: To explore the clinic characteristics and pathogenesis of cryptogenic stroke (CS) patients with right-to-left shunt (RLS). Methods: Patients admitted to the Department of Neurology of our hospital from October 2018 to September 2020 and diagnosed as CS according to TOAST classification were enrolled. All CS patients were examined by contrast-enhanced transcranial Doppler test, and were divided into RLS+ group and RLS− group according to the existence of RLS. Demographic characteristics, risk factors of vascular disease, platelet function, coagulation function, structure and function of heart were compared between two groups. Results: A total of 111 CS patients were enrolled, 55 patients in RLS+ group and 56 patients in RLS− group. In terms of risk factors of vascular disease, RLS+ group had less prevalence of hypertension, diabetes and hyperlipidemia (P