Optimization of Dalbavancin in Patients with Hepatic or Renal Impairment
Open Access
- 1 January 2020
- journal article
- Published by Scientific Research Publishing, Inc. in Pharmacology & Pharmacy
- Vol. 11 (02), 29-37
- https://doi.org/10.4236/pp.2020.112004
Abstract
Dalbavancin is a novel semi-synthetic glycopeptide antibiotic. In this study, we aimed to optimize the dosage regimen of dalbavancin in patients with hepatic or renal impairment by Mote Carlo simulation. Pharmacokinetic parameters and microbiological data were collected about dalbavancin. 10,000 patients with renal or hepatic impairment analyzed by Crystal Ball to calculate probability of target attainment (PTA) and cumulative fraction of response (CFR). We found that all bacterial PTA and CFR were more than 90% for dalbavancin in patients with hepatic or renal impairment, except for Enterococcus faecium. There is no need to adjust the dosage regimen of dalbavancin in patients with hepatic or renal impairment.Keywords
This publication has 1 reference indexed in Scilit:
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