Cellular function of (a)symmetric biological membranes
- 23 December 2022
- journal article
- review article
- Published by Portland Press Ltd. in Emerging Topics in Life Sciences
- Vol. 7 (1), 47-54
- https://doi.org/10.1042/etls20220029
Abstract
In mammalian cells, phospholipids are asymmetrically distributed between the outer and inner leaflets of the plasma membrane. The maintenance of asymmetric phospholipid distribution has been demonstrated to be required for a wide range of cellular functions including cell division, cell migration, and signal transduction. However, we recently reported that asymmetric phospholipid distribution is disrupted in Drosophila cell membranes, and this unique phospholipid distribution leads to the formation of highly deformable cell membranes. In addition, it has become clear that asymmetry in the trans-bilayer distribution of phospholipids is disturbed even in living mammalian cells under certain circumstances. In this article, we introduce our recent studies while focusing on the trans-bilayer distribution of phospholipids, and discuss the cellular functions of (a)symmetric biological membranes.Keywords
This publication has 51 references indexed in Scilit:
- Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic CellsScience, 2013
- In search of a novel target — Phosphatidylserine exposed by non-apoptotic tumor cells and metastases of malignancies with poor treatment efficacyBiochimica et Biophysica Acta (BBA) - Biomembranes, 2011
- Calcium-dependent phospholipid scrambling by TMEM16FNature, 2010
- Differential roles of PtdIns(4,5)P2 and phosphorylation in moesin activation duringDrosophiladevelopmentJournal of Cell Science, 2010
- Lipid outward translocation by ABC proteinsFEBS Letters, 2010
- Organizing the cell cortex: the role of ERM proteinsNature Reviews Molecular Cell Biology, 2010
- Membrane lipids: where they are and how they behaveNature Reviews Molecular Cell Biology, 2008
- Membrane Phosphatidylserine Regulates Surface Charge and Protein LocalizationScience, 2008
- Molecular dynamics investigation of dynamical properties of phosphatidylethanolamine lipid bilayersThe Journal of Chemical Physics, 2005
- Physical properties of surfactant bilayer membranes: thermal transitions, elasticity, rigidity, cohesion and colloidal interactionsThe Journal of Physical Chemistry, 1987