Natural Viruses of Caenorhabditis Nematodes
- 3 December 2019
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 53 (1), 313-326
- https://doi.org/10.1146/annurev-genet-112618-043756
Abstract
Caenorhabditis elegans has long been a laboratory model organism with no known natural pathogens. In the past ten years, however, natural viruses have been isolated from wild-caught C. elegans (Orsay virus) and its relative Caenorhabditis briggsae (Santeuil virus, Le Blanc virus, and Melnik virus). All are RNA positive-sense viruses related to Nodaviridae; they infect intestinal cells and are horizontally transmitted. The Orsay virus capsid structure has been determined and the virus can be reconstituted by transgenesis of the host. Recent use of the Orsay virus has enabled researchers to identify evolutionarily conserved proviral and antiviral genes that function in nematodes and mammals. These pathways include endocytosis through SID-3 and WASP; a uridylyltransferase that destabilizes viral RNAs by uridylation of their 3′ end; ubiquitin protein modifications and turnover; and the RNA interference pathway, which recognizes and degrades viral RNA. Expected final online publication date for the Annual Review of Genetics, Volume 53 is November 23, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.Keywords
This publication has 65 references indexed in Scilit:
- Homologous RIG-I–like helicase proteins direct RNAi-mediated antiviral immunity in C. elegans by distinct mechanismsProceedings of the National Academy of Sciences of the United States of America, 2013
- Competition between virus-derived and endogenous small RNAs regulates gene expression in Caenorhabditis elegansGenome Research, 2013
- Silencing of Host Genes Directed by Virus-Derived Short Interfering RNAs in Caenorhabditis elegansJournal of Virology, 2012
- Conserved tyrosine kinase promotes the import of silencing RNA into Caenorhabditis elegans cellsProceedings of the National Academy of Sciences of the United States of America, 2012
- Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegansCell, 2011
- RNA‐based viral immunity initiated by the Dicer family of host immune receptorsImmunological Reviews, 2008
- RETRACTED: Secondary siRNAs Result from Unprimed RNA Synthesis and Form a Distinct ClassScience, 2007
- Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated PathwaysCell, 2006
- An antiviral role for the RNA interference machinery in Caenorhabditis elegansProceedings of the National Academy of Sciences of the United States of America, 2005
- Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegansNature, 2005