The period from January to March 2021 completed the formation of the main outlines of the foreign policy of the Joe Biden administration in the Middle East, which found its consolidation in the Interim Strategic Leadership in the field of national security. Its main features, in contrast to the policy of the D. Trump administration, are based on the principles of democracy, liberalism and reliance on the alliances and allies of the United States in the region. The main directions of the foreign policy course of the new US administration in the Middle East region are determined as follows: ensuring effective security for Israel in the context of its deep integration into the Middle East, advancing the process of the Abrahamic agreements and resolving the Palestinian-Israeli conflict on the basis of a two-state solution; organizing, together with its regional allies and partners, the effective counteraction to the Iranian expansionist course by returning to an updated and expanded Joint Comprehensive Plan of Action; continuing the counterterrorism activities with reliance on regional partners and improvement of the forms and methods of its implementation; significantly reducing the level of tension in the region. When implementing these tasks, the Biden administration will have to find a balance between the proclaimed principles of its foreign policy in the region and the existing realities and traditions, especially among the Arab countries of the region.