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Triple fixed-dose combination in the treatment of hypertension: the results of the Russian observational study TRICOLOR

Yu. A. Karpov , V.M. Gorbunov , N. A. Logunova
Published: 18 November 2020
Russian Journal of Cardiology , Volume 25; doi:10.15829/1560-4071-2020-4130

Abstract: The article presents the main results of the Russian post-marketing multicenter open-label program TRICOLOR (Triple fixed-dose combination in the treatment of hypertension).Aim. To evaluate the antihypertensive efficacy and tolerability of the triple amlodipine/indapamide/perindopril fixed-dose combination, as well as the adherence of hypertensive (HTN) patients to this therapy in actual clinical practice.Material and methods. The program enrolled 1247 outpatients aged 18 to 79 of both sexes with essential HTN. All patients included in the study receive amlodipine/ indapamide/perindopril fixed-dose combination. The patient’s condition was assessed according to four visits: visit 1 — at inclusion, visit 2 — after 2 weeks, visit 3 — after 4 weeks, visit 4 — after 12 weeks of follow-up. At each visit, the achievement of the target blood pressure (BP) Results. After 12 weeks, a significant decrease in systolic and diastolic BP was recorded — by 33,5 and 14,3 mm Hg, respectively (pConclusion. The results of the TRICOLOR program demonstrate a high antihypertensive efficacy, good tolerance and medical adherence of triple amlodipine/indapamide/perindopril fixed-dose combination in patients with essential HTN in actual clinical practice in Russia.
Keywords: Treatment / Efficacy / Tolerability / Blood Pressure / Fixed Dose Combination / VisIt / amlodipine/indapamide/perindopril / program TRICOLOR

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