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Study on the Role of Vitamin D in Systemic Lupus Erythematosus

Jiadian Wang, Muzi Cui, Siyi Wang, Xiao Xue, Kerong Ren, Zhilu Li, Saijia Li, Pingping Yan

Abstract: Vitamin D is a hormone precursor with multiple biological effects. It binds to vitamin D receptors on target cells. It is an important participant in the metabolism of calcium and phosphorus in vivo. It is closely related to cell cycle, cell proliferation, differentiation, apoptosis, signal transduction and immune regulation. Its role in the treatment of infection, tumor and even immune diseases has been gradually recognized and studied. Patients with systemic lupus erythematosus generally have decreased levels of active vitamin D, and low levels of vitamin D are associated with disease occurrence, disease activity and complications. In the past ten years, a large number of studies have been carried out on it globally to explore the role of vitamin D in the occurrence and development of systemic lupus erythematosus. This paper summarizes its recent research progress.
Keywords: differentiation / apoptosis / Treatment / vitamin / Systemic lupus erythematosus

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