Effect of Azithromycin on Myocardial Resistance to Ischemia/Reperfusion in Systemic Inflammatory Response Syndrome and Alimentary Obesity
- 31 March 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Bulletin of Experimental Biology and Medicine
- Vol. 170 (5), 613-617
- https://doi.org/10.1007/s10517-021-05117-3
Abstract
The study focuses on the effects of azithromycin on severity of ischemia/reperfusion myocardial injury during simulated systemic inflammatory response syndrome (SIRS) in primary visceral obesity (PVO). Total ischemia/reperfusion was modeled by Langendorff perfusion of isolated heart with following estimation of the size of myocardial infarction. SIRS was accompanied by an increase in blood levels of proinflammatory cytokines and LPS. Combination of PVO and SIRS produced no significant changes in the infarct size compared to the control. Administration of azithromycin to rats with PVO and SIRS resulted in pronounced alterations of biochemical and immunological parameters, although it did not affect the infarct size. In contrast, the use of tetracycline increased the size of myocardial infarction. This phenomenon should be taken into consideration in antimicrobial therapy.Keywords
This publication has 10 references indexed in Scilit:
- Modeling of systemic inflammatory response syndrome by chemical induction of colon injury in ratsMedical Immunology (Russia), 2020
- Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitisPLOS ONE, 2019
- The role of intestinal microbiota in cardiovascular diseaseJournal of Cellular and Molecular Medicine, 2019
- Cardio-oncology: cardiovascular complications of cancer therapyFuture Cardiology, 2017
- Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in RatsPLOS ONE, 2016
- A population-based analysis of the risk of drug interaction between clarithromycin and statins for hospitalisation or deathLipids in Health and Disease, 2015
- Intestinal microbiota determine severity of myocardial infarction in ratsThe FASEB Journal, 2011
- Lipid Metabolism by Gut Microbes and AtherosclerosisCirculation Research, 2011
- Updates on Cytochrome P450-Mediated Cardiovascular Drug InteractionsDisease-a-Month, 2010
- Ten years of antibiotic consumption in ambulatory care: Trends in prescribing practice and antibiotic resistance in AustriaBMC Infectious Diseases, 2009