Influence of Administration Route and Dose on Biodistribution Profile and Effects of PEG-PLA Nanoparticles in Mice

Abstract

Polyethylene glycol-polylactic acid nanoparticles (PEG-PLA NPs) represent a new generation of parenteral therapeutics systems. Following administration, these NPs possess the potential to interact with biological machinery. Therefore, it is essential to get a systematic understanding of the biological fate of these NPs to evaluate their safety. In the present study, two doses (20 and 40 mg/kg) of technetium-99m labeled PEG-PLA NPs were administered intravenous (i.v.) and oral into mice and the distribution was assessed at 1, 2, 4 and 24 h post administration. Biodistribution and blood kinetic profiles revealed the extended systemic circulation of the NPs. Dose-dependent presence of NPs (p